Oxitan 50mg/10ml INJECTION

Oxaliplatin, sold under the brand name OXITAN 50MG/10ML among others, is a cancer medication (platinum-based antineoplastic class) used to treat colorectal cancer.^[3] It is given by injection into a vein.^[3]

Common side effects include numbness, feeling tired, nausea, diarrhea, and low blood cell counts.^[3][4] Other serious side effects include allergic reactions.^[4][3] Use in pregnancy is known to harm the baby.^[3] Oxaliplatin is in the platinum-based antineoplastic family of medications.^[5] It is believed to work by blocking the duplication of DNA.^[3]

Oxaliplatin was patented in 1976 and approved for medical use in 1996.^[6] It is on the World Health Organization’s List of Essential Medicines.^[7][8]

Oxaliplatin is used for treatment of colorectal cancer, typically along with folinic acid (leucovorin) and fluorouracil in a combination known as FOLFOX^[9] or along with capecitabine in a combination known as CAPOX^[10] or XELOX.^[11]

Advanced colorectal cancer[edit]

Oxaliplatin by itself has modest activity against advanced colorectal cancer.^[12] When compared with just 5-fluorouracil and folinic acid administered according to the de Gramont regimen, a FOLFOX4 regime produced no significant increase in overall survival, but did produce an improvement in progression-free survival, the primary end-point of the phase III randomized trial.^[13]

Adjuvant treatment of colorectal cancer[edit]

After and/or before the curative resection of colorectal cancer, chemotherapy based on 5-fluorouracil and folinic acid reduces the risk of relapse.^[14